183954
Sigma-Aldrich

*del*1,4-DITHIANE-2,5-DIO

Empform:

C4H8O2S2

Synonyms English:

2,5-Dihydroxy-1,4-dithiane; Mercaptoacetaldehyde dimer

Nacres: NA.22
Mdl No: MFCD00006659
Fw: 152.24
Pubchem Substance Id: 24851084
CAS Number: 40018-26-6
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Properties

Properties
Description *del*1,4-DITHIANE-2,5-DIO
Need written commitment NI0000

Description

Application

1,4-Dithiane-2,5-diol was used in the synthesis of:
  • substituted tetrahydrothiophene derivatives
  • 2-amino-3-(arylsulfonyl)thiophenes, potential antiviral and antitumor agents

General description

1,4-Dithiane-2,5-diol undergoes bifunctional squaramide catalyzed sulfa-Michael/aldol cascade reaction with chalcones to afford trisubstituted tetrahydrothiophenes. It participates in diastereoselective [3+3] cycloaddition with azomethine imines catalyzed by 1,4-diazabicyclo[2.2.2]octane. It is a mercaptoacetaldehyde dimer and an efficient synthon for incorporating a thiol group to in situ generated nitroalkenes.

SAFETY INFORMATION

GHS06,GHS08,GHS09

Signal Word

Danger

H301 - H317 - H330 - H373 - H410

P260 - P273 - P280 - P302 + P352 - P304 + P340 + P310 - P314

RIDADRRIDADR

WGK Germany

WGK 2

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

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