186562
Sigma-Aldrich

TETRAHYDROFURAN, ANHYDROU

Empform:

C4H8O

Synonyms English:

THF

Nacres: NA.21
Mdl No: MFCD00005356
Fw: 72.11
Pubchem Substance Id: 57647757
CAS Number: 109-99-9
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Properties

Properties
assay
assay range 99.9%
availability 610 
average diameter ?F
brush size diam. × l 65-67 
brush size l × diam. ?C (lit.)
cooling capacity 250 
copper content ppm BHT as inhibitor
depth × overall h 0.889 
depth × width g/mL 
Description TETRAHYDROFURAN, ANHYDROU
detection method ?C (lit.)
external size 1.8-11.8 
external w × d × h %
free height above pan liquid
greener alternative product score anhydrous
inlet cga
inlet connection diam. 0.005% peroxides (as H2O2)
inlet connection size 1S/C4H8O/c1-2-4-5-3-1/h1-4H2
inlet diam. WYURNTSHIVDZCO-UHFFFAOYSA-N
Need written commitment NI0000

Description

Application

Dry tetrahydrofuran (THF) has been used in the synthesis of dichloro{bis[1,1′,1′′-(phosphinetriyl)tripiperidine]}palladium [(P(NC5H10)3)2Pd(Cl)2], which is widely used in the Heck reaction as a catalyst. It has been employed in the reaction medium of the Heck cross-coupling reaction of various aryl bromides and olefins.

General description

Tetrahydrofuran (THF) is a saturated cyclic ether mainly used as an organic solvent. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms double hydrate with hydrogen sulfide, crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies.

Other Notes

Greener alternatives are available for many THF applications, 2-Methyltetrahydrofuran (414247) and Cyclopentyl methyl ether (675970)

SAFETY INFORMATION

GHS02,GHS07,GHS08

Signal Word

Danger

H225 - H302 - H319 - H335 - H336 - H351

P202 - P210 - P233 - P301 + P312 - P305 + P351 + P338 - P308 + P313

RIDADRRIDADR

WGK Germany

WGK 1

Flash Point (F)

-6.2 °F - closed cup

Flash Point (C)

-21.2 °C - closed cup

Target Organs

Risk Statement

Supplemental Hazard Statements

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