Gene Editing & Functional Genomics

Sigma-Aldrich® Advanced Genomics offers a complete suite of genome engineering and modulation products and services. Our comprehensive portfolio delivers support for every step of your research, from discovery through translational research to therapeutic impact. Target a single gene or screen a whole genome with fully customizable products. With tools to edit using CRISPR or ZFNs, modulate expression with CRISPRa/i or RNAi, or perform whole genome screens, you’re limited only by your scientific curiosity. And with over 350 years of technical leadership, Sigma-Aldrich® Advanced Genomics offers an unsurpassed breadth of expertise and intellectual property to help you succeed.
CRISPR & Gene Editing
With decades of gene editing experience and an unsurpassed portfolio of CRISPR and ZFN technology patents, Sigma-Aldrich® Advanced Genomics delivers the highest quality reagents for your entire workflow, from early-stage discovery to translational research. Whether you are looking to knockout, knock-in, knockdown, or overexpress your targets, our comprehensive suite of CRISPR gene-editing tools and services will take your research Beyond the Bench.
Genetic Screening
Sigma-Aldrich® Advanced Genomics offers complete solutions for your genetic screens at any scale. Whether you're targeting specific genes or performing a genome-wide screen, we offer extensive pooled and arrayed formats to meet your needs. From gene expression knockdown with CRISPRi and RNAi to overexpression with CRISPRa and ORF, we have everything you need for your target discovery research.
RNAi Libraries
Sigma-Aldrich® Advanced Genomics is the exclusive provider of the TRC1.5 and TRC2 collections from The RNAi Consortium (TRC). These lentivirus-based shRNA libraries deliver unparalleled coverage and are available in multiple formats that include whole-genome, individual RNAi clones/vectors, and gene family sets. Available in standard glycerol format or higher quality DNA and lentiviral formats.
RNAi Single Clones
Sigma-Aldrich® Advanced Genomics RNAi Single Clones deliver powerful, long term, and stable gene silencing. As an exclusive provider of the TRC1.5 and TRC2 collections from The RNAi Consortium (TRC), our comprehensive offering consists of nearly 200,000 pre-cloned shRNA constructs targeting more than 22,500 human and 20,000 mouse genes.